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Diltiazem is both substrate and an inhibitor of the cytochrome ostaa tiazac halvalla ilman reseptia P-450 3A4 enzyme system. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Quinidine Diltiazem significantly increases the AUC of quinidine by 51 Ty, by 36 and decreases its CLoral by 33.